Two people have died following a two-vehicle crash on the Victorian border early this morning.

The crash happened about 6.40am (Wednesday 6 February 2019), when a Volkswagen Passat travelling north on Murray Valley Highway, Euston, and a Holden Colorado travelling south collided in the southbound lanes.

The driver and front passenger of the Volkswagen, both believed to be women aged in their 20s, were airlifted to a hospital in Melbourne in a serious condition.

The two rear passengers died at the scene.

The driver and sole-occupant of the Holden, a woman aged in her 20s, was taken to Mildura Base Hospital with minor injuries.

Officers from Barrier Police District attended and a crime scene was established.

Detectives will investigate the circumstances surrounding the crash and anyone with information or dash cam footage is urged to come forward.

A report will be prepared for the Coroner.

Anyone with information about this incident is urged to contact Crime Stoppers: 1800 333 000 or Information is treated in strict confidence. The public is reminded not to report crime via NSW Police social media pages.